Unprecedented initiative in Brazil to create genetic database of SUS patients

The Support Program for the Institutional Development of the Unified Health System (PROADI-SUS), from the Ministry of Health, will collect data genomic and clinicians of 2,382 oncology and cardiology patients treated at SUS for the unprecedented construction of a database of this type in Brazil. In addition, genetic sequencing for arterial hypertension will be carried out in 2,000 military police officers located in Rio Grande do Sul, as well as the qualification of 300 professionals working in public health in Genomic and Precision Medicine. The initiative will have a national impact and will be led by the BP – The Beneficência Portuguesa Hospital of São Paulo, a health hub of excellence that also forms part of Proadi, in partnership with the Instituto do Coração of the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo (InCor/HCFMUSP).

Named “Mapa Genome Brasil – Precision Medicine in Oncology and Cardiology in the SUS”, the project will contribute to the Brazil Genomes Program, launched in 2020 by the Federal Government with the objective of encouraging scientific and technological development in the areas of genomics and health of precision within the scope of the SUS. The information collected by the Brazil Genome Map is expected to contribute to the implementation of population management strategies in breast cancer, colorectal cancer, prostate cancer and cardiovascular diseases, all of which are considered Chronic Noncommunicable Diseases (NCDs). According to Renato Vieira, executive director of Medical, Technical and Education and Research Development, the project will generate more and more knowledge about how pathologies develop and how they behave in the population, contributing to the development of increasingly effective therapies, as well as prevention strategies.

“Today, when working with genetic sequencing, research or analysis of the care routine, our professionals are based on databases of the American or European population, and Brazil is a country of continental dimensions and characteristics that vary according to each region. . The Brazil Genome Map is a robust and detailed proposal that will bring unprecedented information from the Brazilian population, directly impacting patient care in the SUS. The exponentially growing knowledge of the human genome, combined with solid and well-structured databases, is allowing medicine to act in a personalized and highly efficient way, both from the point of view of new treatments and individualized prevention for patients at risk. The study is a huge opportunity for the recognition of genetic factors in the development of Chronic Noncommunicable Diseases (NCDs) in our population”, says the director.

By the end of 2023, genetic material from patients and family members will be analyzed, with 110 from breast cancer, 50 from colorectal cancer and 22 from prostate cancer, located in eight health centers in all regions of the country. Through the identified variants, the susceptibility to these diseases will be evaluated. It is important to emphasize that the research participants will undergo personalized service.

Genetic sequencing for high blood pressure

As of July 2022, genetic risk stratification for arterial hypertension will be carried out in a group of two thousand military police officers located in Pelotas (RS), through the implementation of a systemic strategy model to actively track individuals with increased genetic risk. for prevalent and complex cardiovascular diseases.

“The results of this study will, in an unprecedented way, determine the population genetic risk for these cases, allowing the discovery of new associated biomarkers. Together, the information generated will be included in clinical-epidemiological algorithms in use to increase their effectiveness and their predictive power necessary for the design of anticipatory strategies on a prevalent disease with high morbidity and mortality”, emphasizes Renato Vieira.

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